Simons built the most successful quantitative fund in history by systematically correcting for publication bias in financial research. Renaissance didn't trust published trading strategies because Simons understood that the strategies that made it into journals were a biased sample — overfitted to historical data and selected precisely because they showed positive results. Instead, his team generated and tested their own hypotheses against raw data, treating published findings as starting points to be rigorously stress-tested rather than trusted at face value. For founders, Simons demonstrates that in any domain where results are selectively reported, building your own evidence base from primary data is more reliable than consuming the curated, bias-filtered conclusions of others.