Simons built Renaissance Technologies on statistical arbitrage — and understood that most apparent patterns in financial data are noise. His team ran rigorous backtests with strict out-of-sample validation, rejecting strategies that only "worked" through data mining. The discipline was refusing to see signal where only noise existed. Founders face the same trap in smaller form every week: A/B tests nursed past their stopping rules, metrics sliced until they tell the story the board wants to hear, cohort analyses that conveniently confirm the roadmap. Simons' lesson is structural: insist on pre-registered hypotheses and out-of-sample validation before acting on any quantitative finding. The cost of p-hacking isn't a bad research paper — it's building strategy on statistical artefacts that dissolve under replication.